It seems that Mojave definitely requires Vinyl Studio to 'confirm access to the microphone'. - and in particular to re-confirm it when Vinyl Studio is updated. I just spent a very frustrating hour trying to figure out why Vinyl Studio had stopped receiving any audio from my ADC. It had been working since updating to Mojave, but as soon as I installed VS 10.0.0 I couldn't get Vinyl Studio to receive audio when my usual ADC was selected.
So a very large THANK YOU to the poster above who figured out that the new Microphone setting in OSX Settings / Security needs to be manually selected to allow Vinyl Studio to receive audio. Other applications seem to be asking for permission to 'access the microphone' - even if they actually mean access to an external ADC. As far as I am aware Vinyl Studio doesn't ask at the moment - but granting it permission manually in System Prefs does the trick.